Corticosteroids for Bacterial Keratitis

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Indecision about corticosteroids for bacterial keratitis: an evidence-based update.

PURPOSE To quantify the effect of topical corticosteroids on bacterial keratitis. CLINICAL RELEVANCE Bacterial keratitis is an economically important infection affecting 1 in 10,000 Americans annually. The predisposing factors, prior ocular health, infecting microorganisms, inflammatory severity, and therapeutic choices can affect the course and outcome. Antibacterial treatment is often curat...

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Use of adjunctive topical corticosteroids in bacterial keratitis.

PURPOSE OF REVIEW Topical corticosteroid use in the setting of infectious keratitis has been a controversial issue. The aim of this review is to provide an update on the evidence for use of topical corticosteroids in addition to antibiotics in bacterial keratitis. RECENT FINDINGS Judicious use of steroids is postulated to limit the inflammatory component of bacterial keratitis, but can theore...

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Topical Corticosteroids in the Management of Bacterial Keratitis.

Bacterial keratitis can cause significant morbidity from ulceration of the cornea and the resultant scarring. The use of steroids to decrease these complications is controversial with arguments for and against their use. The SCUT (Steroids for Corneal Ulcers Trial) was initiated in 2006 to definitively determine whether steroids in bacterial keratitis were beneficial or harmful. While the SCUT ...

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Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT).

OBJECTIVE To determine whether there is a benefit in clinical outcomes with the use of topical corticosteroids as adjunctive therapy in the treatment of bacterial corneal ulcers. METHODS Randomized, placebo-controlled, double-masked, multicenter clinical trial comparing prednisolone sodium phosphate, 1.0%, to placebo as adjunctive therapy for the treatment of bacterial corneal ulcers. Eligibl...

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Topical corticosteroids and fungal keratitis.

The incidence of experimentally produced keratitis with Candida albicans was studied in traumatized rabbit eyes; these eyes, 23 out of 30 treated with 1 per cent hydrocortisone drops, 16 out of 30 treated with 1 per cent medrysone drops, and 12 out of 30 treated with control drops without corticosteroid, developed infection as demonstrated by culture of corneal tissue. The increased number of i...

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ژورنال

عنوان ژورنال: Archives of Ophthalmology

سال: 2012

ISSN: 0003-9950

DOI: 10.1001/archophthalmol.2011.315